I feel like I have already told everyone in the world about this, but wanted to post it to the blog just to make it official.  We got the results to Jane's MRI last night:  her tumor is 16% smaller since starting AZD6244!
The following graph says it all--pay particular attention to the light green segment of the line!

This graph shows Jane's tumor (plexiform neurofibroma, or PN) volume over time, and the effect of the various medications she has taken.

I am on cloud nine!
We are going to continue Jane's reduced dose for now given that she seems to be responding to it, and she has been tolerating this dose very well.  We will have the option to increase the dose later if necessary.  We will return to NIH in the fall for a check-up of her eyes and heart, but won't have another MRI until early December.  I plan to enjoy this moment for a while--it's been a long time since we've had good news!